Dysfunctions in these MALT1-directed pathways are coupled to the potential development of aggressive lymphomas with high resistance to current chemotherapies, as well as to the initiation of an array of immune disorders (Solsona et al. 2022) Full length MALT1 is composed of five domains (Hailfinger et al. 2009) including the N-terminal death domain (DD), two immunoglobulin-like domains (IgL1 and IgL2), the paracaspase or caspase-like domain (Casp) and a third immunoglobulin-like domain (IgL3), followed by an unstructured C-terminal tail domain (Fig. 1A). This evidence concerns the gene MALT1 and lymphoma.