Accordingly, MIF not only signals through its cognate receptor CD74/invariant chain, but engages in high-affinity interactions with the CXC chemokine receptors CXCR2 and CXCR4 to promote atherogenic monocyte and T-/B-cell recruitment, cancer metastasis, and inflammation [17, 25, 26, 27, 28, 29, 30]. This evidence concerns the gene MIF and cancer.