Modulation of Kv3.1 and Kv3.2 channels leads to increased firing frequency of fast-spiking GABAergic interneurons and improves gamma oscillation regularity, which is thought to be a marker of the cortical excitation-inhibition balance that is disrupted in schizophrenia (Boddum et al. 2017; Andrade-Talavera et al. 2020). Here, KCNC2 is linked to schizophrenia.