Intriguingly, one patient (P-Ger) also had high serum IgE levels (Fuchs et al., 2016), whereas another (P-Jap) also had eczema and staphylococcal skin infections, as seen in patients with hyper-IgE syndrome (HIES; Fuchs et al., 2016; Minegishi et al., 2006). This evidence concerns the gene IGHE and hyper-IgE syndrome.