Moreover, 60% had viral diseases (due to HSV-1, VZV, influenza A virus, SARS-CoV-2, respiratory syncytial virus [RSV], EBV, CMV, and MMR), and 16% had fungal diseases (mainly due to C. albicans, with chronic mucocutaneous candidiasis in one case), which is more common in patients with IL-12Rβ1 or IL12p40 deficiencies, due to the impairment of IL-17 immunity (Puel et al., 2011; Kreins et al., 2015; Li et al., 2019). This evidence concerns the gene IL12RB1 and viral infectious disease.