P2 (E19-25Del/E19-25Del) is homozygous for a newly identified large deletion that removes the last six exons of TYK2. She suffered from atopy, cellulitis, viral (HSV), mycobacterial (BCG-osis), and parasitic (Leishmania major) infections, with one episode of oral thrush due to Candida albicans. This evidence concerns the gene TYK2 and infection.