TYK2 and viral load: We studied the cellular basis of mycobacterial and viral diseases in TYK2-deficient patients by studying peripheral blood mononuclear cells (PBMCs) from P-Tur (L767*/L767*), P1 (C70Hfs*21/C70Hfs*21), and P11 (P216Rfs*14/P216Rfs*14).