We found that 48% of the 25 patients with AR complete TYK2 deficiency had mycobacterial diseases (due to BCG, EM, or M.tb) and 16% had salmonellosis, brucellosis, or leishmaniasis, as often reported in patients with MSMD (de Beaucoudrey et al., 2010; Fieschi et al., 2003; Parvaneh et al., 2017; van de Vosse et al., 2013). This evidence concerns the gene TYK2 and brucellosis.