Patients with syndromic MSMD display associated phenotypes: patients with ISG15 deficiency have features of type I interferonopathy (Bogunovic et al., 2012; Martin-Fernandez et al., 2020; Zhang et al., 2015), patients with RORγ/RORγT deficiency have chronic mucocutaneous candidiasis (Okada et al., 2015), patients with ZNFX1 deficiency have monocytosis (Le Voyer et al., 2021), the only patient with T-bet deficiency reported to date has airway hyperresponsiveness (Yang et al., 2021), and patients with JAK1 or TYK2 deficiencies have viral diseases (Eletto et al., 2016; Kreins et al., 2015). This evidence concerns the gene TYK2 and Mendelian susceptibility to mycobacterial diseases.