However, it is increasingly clear that not all anti-MDA5 antibodies are made equal: in a recent study, Anti-MDA5 IgG-1 were found to be associated with RP-ILD and Anti-MDA5 IgA were found to be common, while the IgM isotype was more unusual [17]. The gene discussed is IFIH1; the disease is retinitis pigmentosa 1.