While sphingomyelin levels were decreased in bone marrow of Ac KO mice compared to Ac WT mice on day 0 (Figure 5D, left panel), they were significantly enhanced on day 7 in the presence (Figure 5D, right panel) and absence (Figure 5—figure supplement 1) of the infection, correlating with increasing reticulocyte frequencies observed before. Here, ASAH1 is linked to infection.