CFHR1 and cancer: Specifically, we included four cancer cell lines of different tissue origins (i.e., A549 lung, HCT116 colon, MCF7 breast, and SKOV3 ovarian cancer cells, Fig 1A) with largely different genetic backgrounds (i.e., mutations (Ikediobi et al, 2006)) and basal metabolic states (Ortmayr et al, 2019) (Appendix Fig S1), and two nontransformed fibroblast cell lines (i.e., CCD1070Sk (Liu et al, 2007) and HFL1 (Coller et al, 2006)) previously used to model cellular quiescence in vitro (Coller et al, 2006; Liu et al, 2007).