CD8A and cancer: Moreover, innate immune signaling involving cGAS–STING complements the DNA-damaging capacity of RT with the CD8+ cytotoxic T cell-mediated destruction of cancer cells.11 Specific members of the gut microbiota interact with immune cells to promote tumor clearance, suppress cancer cell metastasis, and inhibit chronic inflammation.12 Gut microbiota regulate systemic antiviral immunity via the cGAS–STING–IFN-I axis, promoting host resistance to systemic viral infections.13