The clinical efficacy of radiotherapy (RT) is attributed to its ability to induce DNA damage, which can result directly in tumor-cell death; however, there is an emerging appreciation for additional antitumor immune responses generated by RT and the remodeling of the tumor microenvironment (TME).10 RT-induced DNA damage promotes the activation of the cytosolic DNA sensing pathway mediated by cyclic GMP–AMP (cGAMP) synthase (cGAS) and stimulator of interferon genes (STING). This evidence concerns the gene STING1 and neoplasm.