CGAS and neoplasm: The clinical efficacy of radiotherapy (RT) is attributed to its ability to induce DNA damage, which can result directly in tumor-cell death; however, there is an emerging appreciation for additional antitumor immune responses generated by RT and the remodeling of the tumor microenvironment (TME).10 RT-induced DNA damage promotes the activation of the cytosolic DNA sensing pathway mediated by cyclic GMP–AMP (cGAMP) synthase (cGAS) and stimulator of interferon genes (STING).