This study found that lncRNA PCAT1 was abnormally highly expressed in exosomes of colorectal cancer cells and determined that PCAT1 can promote the occurrence of EMT in circulating tumor cells by regulating the miR-329-3p/netrin-1 axis and ultimately promote colorectal cancer liver metastasis progression, helping us better understand the mechanism of long noncoding RNAs in the progression of colorectal cancer and providing new ideas for colorectal cancer targeted therapy. Here, PCAT1 is linked to neoplasm.