As Auranofin was shown to prevent SARS-CoV-2 replication (Biji et al., 2021; Rothan et al., 2020), we evaluated the effect of Auranofin on NF-κB pathway 48 h following SARS-CoV-2 infection (MOI 0.05) in Calu-3 cells (epithelial cells from a lung adenocarcinoma). Here, NFKB1 is linked to lung adenocarcinoma.