INS and Insulin resistance: Demonstrated that lacking the IL-17 cytokine receptor (IL-17RA−/−) mice in the HFD group exhibited increased intestinal permeability, with increased levels of LPS in vat of IL-17RA−/− compared with C57BL/6 wild-type (WT) mice, suggesting that LPS may negatively affect insulin signaling and aggravate insulin resistance in these mice.