During sepsis-induced damage to the blood-gas barrier, there is obvious attenuation and translocation of the tight junction proteins (including ZO-1, Claudin 5 and Occludin) in the alveolar epithelial cell membrane, demonstrating that the tight junctions are disrupted (Shirvaliloo, 2021; Pang et al., 2022). Here, CLDN5 is linked to Sepsis.