Limited evidence in periodontitis revealed that P. gingivalis, Mycoplasma salivarium, Treponema denticola surface protein Td92, E. faecalis, and LPS can induce pyroptosis in macrophages through the NLRP3/caspase-1/GSDMD pathway, contributing to the pathogenesis and development of periodontitis (Jun et al., 2012; Sugiyama et al., 2016; Li et al., 2019; Li et al., 2020; Ran et al., 2021). This evidence concerns the gene CASP1 and periodontitis.