IL1B and periodontitis: Taken together, the literature shows that an increased level of pyroptosis in periodontitis can promote the secretion of active inflammatory factors (IL-1β, IL-18), thus amplifying the inflammation response, leading to an overactive immune response; this ultimately decreases bone formation, enhances bone resorption by upregulation of RANKL, exacerbates the destruction of periodontal tissue, and suppresses its regeneration (Figure 1).