GSDMD and infection: The PANoptosome was regarded as a platform that acts as a sensor and executor during infection; it was initially shown to consist of NLRP3, NLRC4, AIM2, ASC, TNFR1, RIPK1, RIPK3, MLKL, caspase-1/3/7/8, and GSDMD (Samir et al., 2020).