Therefore, to confirm the role of CD4+ T-cells during HF, we developed a transgenic mouse model by breeding CD4-Cre mice (Jackson Strain # 022071) with Rosa26-iDTR (inducible Diphtheria Toxin Receptor) mice (Jackson Strain # 007900) containing simian diphtheria toxin receptor (DTR) inserted into the ROSA26 locus. The gene discussed is HBEGF; the disease is hydrops fetalis.