Similarly, the inhibition of lncRNA myocardial infarction-associated transcript (MIAT) limits the phosphorylation of extracellular signal-regulated kinase (p-ERK), increases the phosphorylation of ETS transcription factor (p-ELK1) accumulation in the nucleus, and subsequently decreases early growth response 1 (EGR1) expression, thereby regulating the proliferation of smooth muscle cells (SMCs) through the EGR1-ELK1-ERK pathway. Here, EGR1 is linked to myocardial infarction.