PVT1 and Alzheimer disease: In AD, another lncRNA, PVT1 expression was upregulated, while the downregulation of lncRNA plasmacytoma variant translocation 1 (PVT1) expression led to an increase in α-SMA and SM22α expression and decreased MMP-2 and MMP-9 expression by targeting miR-27b-3p, which inhibited phenotypic transition and suppressed proliferation and migration in PDGF-BB-treated HASMCs (83).