SMAD3 and triple-A syndrome: In AAA tissues and AngII-stimulated VSMCs, the expression of lncRNA CRNDE was downregulated, and the data suggest that overexpression of lncRNA CRNDE can promote VSMC proliferation and inhibit apoptosis by upregulating Bcl-3 ubiquitination of Smad3 protein and upregulating smad3 expression, thereby inhibiting mouse AAA growth (74).