PROS1 and cardiac hypertrophy: Aberrant phosphorylation patterns occurred on proteins linked to disparate subcellular compartments, ranging from sarcomeric proteins (LIM domain-binding protein 3, LDB3; myozenin 2, MYOZ2; titin, TTN), to nuclear-localized proteins (BAG family molecular chaperone regulator 3, BAG3; high mobility group protein HMG-I/HMG-Y, HMGA1) with established links to cardiac contractile function, cardiac hypertrophy and/or cardiomyopathy (Figure 4B and Supplementary Table 2).