Through verifying the expression levels of these hub genes in 53 recruited participants and another CHD dataset, we identified five critical genes that included CD83, CXCL2, JUN, CXCL8, and NR4A2. Various studies demonstrated that the gene expression could generally be down-regulated and even silenced by combining with miRNAs; however, upstream circRNAs could intervene with miRNAs response elements (10). The gene discussed is CXCL8; the disease is coronary artery disorder.