In 2013, Haas et al. detected different patterns of DNA methylation in left ventricular tissues obtained from DCM patients and reproduced epigenetic regulation patterns of several genes with previously unknown functions in DCM, including lymphocyte antigen 75 (LY75), tyrosine kinase-type cell surface receptor HER3 (ERBB3), Homeobox B13 (HOXB13), and adenosine receptor A2A (ADORA2A) (13). This evidence concerns the gene ADORA2A and familial dilated cardiomyopathy.