APOE and coronary atherosclerosis: In addition, ApoE–/–:Ins2+/Akita male mice fed a Western diet (hyperglycemic and hyperlipidemic mice) also have coronary atherosclerosis, MI and a significant reduction in lifespan (67), while chronic intermittent mental stress promotes plaque instability and MI in ApoE(–/–)fibrillin-1 (C1039G±) mice (68).