CD274 and neoplasm: The research conducted by He and colleagues has unraveled that infiltrating neutrophils express a higher frequency of PD-L1 in the presence of GM-CSF and TNF-α in TME; In turn, the PD-L1+ neutrophils effectively impaired anti-tumor immunity via suppressing the proliferation and activation of T cells through the PD-L1/PD-1 signaling axis (76).