In the present study, we found that CRF after breast cancer chemotherapy disrupted tight junction proteins (ZO-1, occludin, and claudin-5) in the gut barrier and stimulated inflammatory cytokine responses (IL-1β, IL-6, and TNF-α) in the gut and hippocampus, which were significantly reversed by acupuncture treatment. This evidence concerns the gene OCLN and breast carcinoma.