When we stratified the CRD into parenchymal lung lesions (including lung cancer and TB) and airway disease (including COPD, tracheitis/bronchitis, and asthma), we found that both parenchymal lung lesions and airway disease had higher insulin use ratios (40.20%, 28.52%, all p’s <.0001, respectively). This evidence concerns the gene INS and chronic obstructive pulmonary disease.