In summary, through a variety of bioinformatics methods, our research successfully identified 5 key Ferr-DEGs associated with primary osteoporosis and ferroptosis, namely, SIRT1, HSPA5, MTOR, HIF1A and BECN1. In addition, autophagy may also be involved in ferroptosis-related primary osteoporosis. This evidence concerns the gene SIRT1 and osteoporosis.