We considered the trends of protein and gene expression in tissues and intersected most of those algorithms as the 5 most likely key Ferr-DEGs, including SIRT1, HSPA5, MTOR, HIF1A and BECN1. Ultimately, these 5 key Ferr-DEGs were considered to be a preliminary reference for determining whether they are differentially expressed when osteoporosis occurs. Here, HIF1A is linked to osteoporosis.