TGFB1 and chronic kidney disease: C-X3-C motif chemokine receptor 1 (CX3CR1), also known as CCRL1, is identified as a chemokine receptor that selectively targets mouse kidney dendritic cells (DCs), which accumulate in the tubulointerstitium of CKD and produce human transforming growth factor-β (TGF-β) to drive the development of fibrosis and progression of CKD [29, 30].