EGF and gastroesophageal reflux disease: Even though it was reported that 90% of esophageal cancer show EGFR upregulation [35] and a recent meta-analysis found EGFR overexpression to be a predictive biomarker in clinical practice (because of its correlation with the clinicopathological features and overall survival prognostic value [36]), our study revealed no differences in EGF and EGFR mRNA expressions in esophageal tissues with or without endoscopically visible pathological changes in GERD patients.