EGFR and esophageal cancer: In addition, the EGF-EGFR interaction, especially the genotypes AA +61 EGF A>G (rs4444903; phenotype with low expression of EGF) and GG +142285 G>A EGFR (rs2227983), were shown to increase (2.5-fold) the susceptibility to esophageal cancer in a group of 159 patients with ESCC and 15 patients with EAC in comparison with a group of 196 endoscopically unexamined controls from the Indian population [27].