A total of 407 individuals, including 301 patients with GERD and 106 persons in Group 2 (98 patients with NERD and 8 healthy control), were genotyped for +61 A>G EGF (rs4444903) and +142285 G>A EGFR (rs2227983) polymorphisms. The gene discussed is EGFR; the disease is gastroesophageal reflux disease.