In addition, none of the EGF-EGFR genotypes interactions showed effects on the risk of developing GERD or its complications in comparison with reference genotypes EGF-EGFR AG-AA, AG-AG, GG-AA, and GG-AG (p > 0.05; see Tables 3–4), adjusted for age and sex. This evidence concerns the gene EGFR and gastroesophageal reflux disease.