HBEGF and ocular melanoma: We previously assessed the potential role of growth factors in hyperplasia and identified heparin-binding epithelial growth factor (HB-EGF) as strongly up-regulated during ME mucosal growth (Hernandez et al., 2015) and more capable of stimulating the proliferation of mucosal explants in culture than other epithelial growth factors expressed during OM (Suzukawa et al., 2014).