Further validation was performed in another expression profile of AD, GSE33000 (Narayanan et al., 2014), and the result implied high sensitivity and specificity of DGKG, MAP3K7IP2, NFKBIE, VIP, and PCCB for diagnosing Alzheimer’s disease (combined AUC = 0.9388; Figure 4E). The gene discussed is PCCB; the disease is early-onset autosomal dominant Alzheimer disease.