AKT1 and colonic neoplasm: Scholars have expounded on the different mechanisms of CircPUM1 in different cancers, including regulating the mir-524-5p axis of colon cancer, circc3p1/mir-21, tumor-suppressor gene PTEN, and NF-κB and PI3K/Akt pathways (Zhao et al., 2016; Su et al., 2020).