Compared to normal bone tissues, infiltration of endothelial cells (p < 0.01) and B cells (p < 0.01) was increased, whereas infiltration of cancer-associated fibroblasts (p < 0.05), NK cells (p < 0.05), and CD4+ T cells (p < 0.05) was decreased in Ewing sarcoma samples, which suggested that these immune cells had a significantly prognostic value for Ewing sarcoma (Figure 3B). This evidence concerns the gene CD4 and cancer.