While, the heatmap showed the co-expression patterns between CD4+ T cells and CD8+ T cells (R = 0.53); CD4+ T cells and macrophages (R = 0.51); endothelial cells and macrophages (R = 0.47); CD8+ T cells and macrophages (R = 0.72), indicating a strong correlation between these immune cells in Ewing sarcoma (Figure 3C). The gene discussed is CD4; the disease is Ewing sarcoma.