After adjusting for tumor purity, the survival risk of XBP1 overexpression was significantly increased in kidney renal papillary cell carcinoma (KIPR), brain lower grade glioma (LGG) and uveal melanoma (UVM) but decreased in LUAD, mesothelioma (MESO), OV, pheochromocytoma and paraganglioma (PCPG), SKCM and THYM (Figure 1C). The gene discussed is XBP1; the disease is neoplasm.