A bubble chart based on seven different algorithms showed that the risk score was positively correlated with myeloid dendritic cells, cancer-associated fibroblasts, M2 macrophages, B cells, hematopoietic stem cells, T cell CD8+, and mast cells while negatively correlated with NK cells, M1 macrophage, T cell CD4+ Th1, and T cell CD4+ Th2 (all p < 0.05, Figure 9B, Supplementary Table S7). This evidence concerns the gene CD8A and cancer.