The mutation frequencies of somatic adenomatous polyposis coli (APC) and Kirsten rat sarcoma virus (KRAS) are lower in epithelial tumor tissue from patients with IBD-related CRC, while tumor protein P53 (TP53) mutations and Myc proto-oncogene protein (MYC) amplifications are detected earlier during tumor progression in comparison to sCRC (Lucafò et al., 2021; Rajamäki et al., 2021). Here, MYC is linked to colorectal carcinoma.