In our study, among the three different m5C clusters, cluster C had more immune characteristics and metabolism-related pathways than did clusters A and B. For example, cluster C was characterized by a higher number of immunocytes and immune response reactions, which included a greater abundance of plasmacytoid dendritic cells (pDCs) and interferon receptors, the former of which are increased in MM patients’ bone marrow and play a key role in the progression of MM (Ray et al., 2015). This evidence concerns the gene IFNAR2 and Miyoshi myopathy.