When we analyzed the most interconnected and highly correlated members of the modules which highly correlated with disease state, we found numerous genes with known association with HCC, including IMPDH2 (He et al., 2018), COL24A1 (Yan et al., 2020), RACK1 (Cao et al., 2019), SNRPD2 (Liu et al., 2022) and the hub genes RPL5 and TLK1 (Segura-Bayona et al., 2020; Ye et al., 2022). The gene discussed is RPL5; the disease is hepatocellular carcinoma.