RAC1 and hepatocellular carcinoma: Rho family GTPases regulate various cellular functions (Xue et al., 2006) and play an important role in HCC carcinogenesis and metastasis (Wang et al., 2013), particularly GTPase RAC1 (Xue et al., 2006; Yang et al., 2010; Wu et al., 2011; Wang et al., 2013; Bayo et al., 2021).