When we analyzed the most interconnected and highly correlated members of the modules which highly correlated with disease state, we found numerous genes with known association with HCC, including IMPDH2 (He et al., 2018), COL24A1 (Yan et al., 2020), RACK1 (Cao et al., 2019), SNRPD2 (Liu et al., 2022) and the hub genes RPL5 and TLK1 (Segura-Bayona et al., 2020; Ye et al., 2022). This evidence concerns the gene COL24A1 and hepatocellular carcinoma.