The NLRP3 inflammasome alters the tumor microenvironment via secretion of pro-inflammatory cytokines IL1B (neutral in both cohorts) and IL18 (neutral in mKRAS, conserved in WT, SR = -1.144) (Kelley et al., 2019; Swanson et al., 2019). The gene discussed is IL18; the disease is neoplasm.