CTLA4 and cancer: Hereon, we didn’t see the correlation of m7G score with OS in STAD, but our results indicated that m7G scores were negatively related to many immuno-suppressive genes like PDCD1, CTLA4 and LAG3 through various cancers, and we verified with clinic data showing high m7G scores corelated to the low OS in advanced and advanced clear cell RCC when using immune checkpoint blockade therapy.