We found that more differential expressed genes (≥20 out of 29 regulator genes, |logFC|>1, p < 0.05) were harbored in Cholangio Carcinoma (CHOL), Lymphoid Neoplasm Diffuse Large B-cell Lymphoma (DLBC), Pancreatic Adenocarcinoma (PAAD) and Thymoma (THYM) (Figure 1A), and 5 main differential expressed regulator genes (EIF4E1B, METTL1, NUDT11, NUDT10 and NUDT4B) were distributed in more than 15 cancer types (|logFC|>1, p < 0.05). The gene discussed is EIF4E1B; the disease is pancreatic adenocarcinoma.