CTLA4 and cancer: It is notable that most immuno-suppressive genes were negatively related to m7G scores through 33 cancers, such as famous drug targets PD1 (gene: PDCD1, ≥30 cancers), CTLA4 (gene: CTLA4, ≥27 cancers) and the next immune checkpoint receptor LAG3 (Ruffo et al., 2019) (gene: LAG3, ≥27 cancers).