TP53 and cancer: As shown in Figure 4, a subgroup of genes regulated by Myc-version 1 (Myc targets V1), unfolded protein response, protein secretion, G2M checkpoint, mitotic spindle, MTORC1 signaling, and PI3K AKT MTOR signaling were positively corelated with m7G score in most cancer types (≥30 cancers), while genes down-regulated by KRAS activation (KRAS signaling DN), myogenesis, xenobiotic metabolism, coagulation and p53 pathway were negatively corelated with m7G score in some cancers (≥23 cancers).