PRKAR1A and neoplasm: A molecular genetic study demonstrated that more than 70% of CNC patients have mutations in the PRKAR1A gene, which is a classic tumor suppressor gene that encodes for the 1-α regulatory subunit (R1α) of the cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) (Kirschner et al., 2000; Bertherat et al., 2009).