The present study found that levels of expression of five cuproptosis-related genes, ATP7B, DBT, DLAT, LIAS, and PDHB, differed significantly in ccRCC and adjacent nontumorous kidney tissue and that a gene signature involving these five genes may be independently prognostic of OS in patients with ccRCC. This evidence concerns the gene ATP7B and nonpapillary renal cell carcinoma.