CDH1 and cancer: Epithelial-mesenchymal transition (EMT), which is characterized by the loss of epithelial cell markers epithelial-cadherin (E-cadherin), as well as the increased expression of the mesenchymal proteins such as N-cadherin, Vimentin, α-smooth muscle actin (α-SMA), and the EMT-transcription factors Snail, Slug, Twist, ZEB (Wang et al., 2018), is an essential process in invasion and metastasis of cancer cell (Dong et al., 2019).