For example, B029-2 (a novel p300 inhibitor) disrupts the metabolic reprogramming of HCC cells by reducing H3K18Ac and H3K27Ac levels at the promoter regions of amino acid metabolism and nucleotide synthesis enzyme genes, and thus is a potential drug for the treatment of HCC (Cai et al., 2021). The gene discussed is EP300; the disease is hepatocellular carcinoma.