Histone acetyltransferase PCAF also accelerates apoptosis by repressing pro-apoptotic gene BCL2-Associated X (Bax) axis or acetylating histone H4 and inactivating AKT signaling in HCC (Zheng et al., 2013; Gai et al., 2015). Here, AKT1 is linked to hepatocellular carcinoma.