β-catenin pathway is one of the critical regulatory pathways in EMT process and cancer metastasis, and the acetylated status of β-catenin or the upstream signal protein kinase B (PKB) might mediate the canonical Wnt pathway in HCC (Chen et al., 2013; Yuan et al., 2020; Han et al., 2021). The gene discussed is AKT1; the disease is hepatocellular carcinoma.