TP53 and hepatocellular carcinoma: Treatment of pan-deacetylase inhibitor panobinostat or inducing p53 protein acetylation provide a novel therapeutic strategy for HCC by inducing apoptosis and inhibiting hepatoma cell growth (Zhu et al., 2009; Park et al., 2012; Song et al., 2013; De Matteis et al., 2018; Lim et al., 2020).