However, mechanisms of anticancer effects of HDAC inhibitors are not uniform, which may depend on the cancer type, HDAC inhibitors, doses, etc. In addition to designing inhibitors against the aberrant activity of HDAC, targeting other key molecules that regulate acetylation has also been shown to exert significant effects in anti-HCC therapy, although data are limited. Here, HDAC9 is linked to hepatocellular carcinoma.