In models of stroke, epilepsy, and amyotrophic lateral sclerosis, a decrease of CX3CR1 or a rise of its ligand seem to be protective (Soriano et al., 2002; Cipriani et al., 2011; Yeo et al., 2011; Xu et al., 2012; Fumagalli et al., 2013; Tang et al., 2014; Liu et al., 2019). Here, CX3CR1 is linked to stroke disorder.