BDNF and androgen insensitivity syndrome: At baseline (Day 1), AIS patients showed higher concentrations of MMP-9 and BDNF than healthy controls (MMP-9 [69.67 ± 20.56 vs. 41.52 ± 15.13], BDNF [5.76 ± 3.00 vs. 1.13 ± 0.35], all P < 0.001, Figure 2).