Finally, we showed that AD pathological proteins, Aβ oligomers and mutant tau, both of which impact autophagy and F-actin dynamics pathways (Fulga et al., 2007; Caccamo et al., 2010; Woo et al., 2015b; Cabrales Fontela et al., 2017; Fang et al., 2021), increased sEV secretion and are also contents of secreted sEVs. Here, MAPT is linked to Alzheimer disease.