OPTN and Alzheimer disease: Interestingly, autophagy cargo receptors, such as Sqstm1/p62 and optineurin, are often found in secreted exosomes (Gudbergsson and Johnsen, 2019), while they play vital roles in the clearance of misfolded proteins such as tau in AD (Xu et al., 2019; Woo et al., 2020; Fang et al., 2021; Roca-Agujetas et al., 2021a,b).