Apart from AD, abnormal aggregation of tau protein also is central to a family of protein-misfolding diseases called tauopathies, including primary age-related tauopathy, Pick’s disease, corticobasal syndrome (CBS), progressive supranuclear palsy (PSP), and chronic traumatic encephalopathy (Liu and Gong, 2008). Here, MAPT is linked to supranuclear palsy, progressive, 1.