In line with these reports, our previous studies have revealed the key roles of kainic acid (KA)—an analog of the excitotoxin glutamate—in the deposition of Aβ and tau hyperphosphorylation in APP23 and microtubule-associated protein tau (MAPT) Tg mice, which serve as animal models of AD (Ruan et al., 2019; Zheng et al., 2019). The gene discussed is MAPT; the disease is Alzheimer disease.