As AD is pathologically characterized by the presence of Aβ and tau protein in the brain, especially in the hippocampus (Ruan et al., 2019; Zheng et al., 2019), we therefore establish APP23/MAPT mice to investigate the roles of LEV in antagonizing the effects of KA on inducing the production and deposition of Aβ and p-tau. The gene discussed is MAPT; the disease is Alzheimer disease.