NECTIN2 and Alzheimer disease: In a previous GWAS study, specific alleles of “Translocase of Outer Mitochondrial Membrane 40” (TOMM40) and “Nectin cell adhesion molecule 2” (NECTIN2; i.e., PVRL2) were found to be associated with an increased risk of developing both DM and AD (Hao et al., 2015).