Finally, we proposed lncRNA/miRNA pairs; hsa-miR-124-3p/KCNQ1OT1, hsa-miR-124-3p/NEAT1, and hsa-miR-124-3p/XIST, all of which are expressed in the brain, as new candidate biomarkers for the occurrence of DM and AD simultaneously. Here, KCNQ1OT1 is linked to diabetes mellitus.