GINS2 and cancer: In malignant cancers, such as cervical cancer, GINS2 was significantly upregulated in cancer cells and tumor tissues with an inverse correlation to overall survival in cervical cancer patients [34], whereas in thyroid cancer, GINS2 overexpression initiated the cancer cell proliferation and suppressed the apoptosis via LOXL2 and CITED2 mediation [35, 36].