In this regard, VE-cadherin is an essential molecule involved in angiogenesis during embryonic development (Vestweber, 2008), cancer progression (Li et al., 2017; Han et al., 2018), wound healing (Cao and Schnittler, 2019) and corpus luteum formation (Nakhuda et al., 2005; Maroni and Davis, 2011). Here, CDH5 is linked to cancer.