In a hyperglycemia cell model, characterized by increased ER to mitochondria Ca2+ shuttling and increased mtROS production and Aβ production, transglutaminase 2 (TGM2) increased MERCS by stabilizing the IP3R–Grp75–VDAC interaction (previously discussed in Section 2.2 ER to mitochondria Ca2+ shuttling). This evidence concerns the gene TGM2 and Hyperglycemia.