For example, cetuximab-induced ADCC can stimulate IFN-γ secretion from NK cells, improving NK and DC crosstalk, but it also induces PD-L1 expression and therefore inhibits active T and NK cells, which assists tumor immune escape of HNSCC (Bauman and Ferris, 2014). This evidence concerns the gene CD274 and head and neck squamous cell carcinoma.