By blocking LAG-3 through the infusion of anti-mouse LAG-3 antibodies, the investigators observed an inhibition of tumor progression in mice, along with a significant increase in the antitumor response mediated by CD8+ T cells and a consequent reduction in the number of immunosuppressive cells, such as Tregs, and MDSCs, in the HNSCC mouse model. This evidence concerns the gene CD8A and head and neck squamous cell carcinoma.