Subsequently, Xiong et al. found that lactate in tumor microenvironment promoted the sustained immunosuppressive activity of tumor-infiltrating myeloid cells via the lactylation-Mettl3-m6A-Jak/Stat3 path, thus providing new clues for the development of immunotherapeutic strategies in colorectal cancer (Xiong et al., 2022). This evidence concerns the gene STAT3 and neoplasm.