Similarly, increased histone lactylation levels in NSCLC cells can also down-regulated the expression of glycolytic genes, such as HK1, glucose-6-phosphate dehydrogenase (G6PD) and PKM, attenuating glycolysis and maintaining mitochondrial homeostasis (Jiang J. et al., 2021). This evidence concerns the gene G6PD and non-small cell lung carcinoma.