Pan et al. found that H4K12la was elevated at the promoters of glycolytic genes, including Hif1a, Pkm, and Ldha etc., which further activated glycolysis and facilitated the formation of vicious feedback loop, termed glycolysis/H4K12la/Pkm2, in inflammatory microglia that drive the pathogenesis of AD (Pan et al., 2022) (Figure 2). Here, PKM is linked to Alzheimer disease.